Tobacco Documents Online

L a HK0270014 T 27426 EFFECTS OF SMOKE ON TOLERA,~ICE OF RATS TO HYPOXIA J APPL PHYsIoL 30(3); 352-357j 1971 ATLA~D, PD~RUBACH, HF, PARKER, MG, DIETER, MP, MURAYAMA, M/ CONIVAY, WL, CRIST, CF ~, 5, 7 THE EFFECTS OF SMOKE FROM BOTH TOBACCO AND CORN SILK CIGAREttES (NO NICOTINE) ON THE TOLERANCE OF RATS TO HYPOXIA ARE INVESTIGATED TO DETERMINE THE POSSIBLE PHYSIOLOGICAL EFFECTS OF INGREDIENTS OF TOBACCO SMOKE OTHER THAN CARBON MONOXIDE (CO), ~ETHODS~ SURVIVAL RATESI RESPIRATORY RATESs BODY TEMPERATURES, GLYCOLYTIC PARAMETERS, AND BLOOD CARBON MONOXIDE LEVELS WERE EX- AMINED IN HALE SPRAGUE DAWLEY RATS AFTER TOTAL BODY EXPOSURE FOR .... , HOURS TO THE SMOKE OF TOBACCO OR CORN SILK CIGARETTES, OR 0,045~ CARBON MONOXIDE (WITHOUT SMOKE)~ AT DIFFERENT DEGREES OF HYPOXIA (OXYGEN CONCENTRAT I ON-02), FN~S_L ALL RATS SURVIVED 4-HR EXPOSURES TO TOBACCO SMOKE OR CORN SILK SMOKE IN 2D.9 AND IN 11,~ 02, THE MORTALITY OF RATS EXPOSED TO TOBACCO SMOKE HAS GREATER THAN THOSE EXPOSED TO CORN SILK SMOKE IN 10.4, 8.3, AND 6,6% 02, RATS EXPOSED TO C0 IN 8,3% 02 HITHOUT SMOKE HAD A HIGHER SURVIVAL THAN RATS EXPOSED TO TOBACCO SMOKE IN 8,~I02, HOHEVER, CARBOXYHEMOGLOBIN (COHB) CONCENTRATIONS WERE EQUIVALENT, BOTH TYPES OF SMOKE PRODUCED AN IMMEDIATE REDUCTION IN BREATHING RATE AT ALL 02 CONCENTRATIONS, BUT CO ALONE HAD NO SUCH EFFECT, HYPOTHERHIA PRODUCED BY HYPOXIA WAS INTENSIFIED ONLY BY EXPOSURE TO TOBACCO SMOKE, BLOOD GLUCOSE AND SERUM LACTIC ACID VALUES HERE HIGHER IN RATS IN TOBACCO THAN IN CORN SILK SMOKE AT ALL HYPOXIC LEVELS, THE CRITICAL 02 CONCENTRATION WHICH PRODUCED EI-t.;~ 98 COHG 0'1020

I HK0270015 27426 "EXCESS LACTATE;" AN INDEX OF ANAEROBIC MET/~3OLISM'~ HAS 6,6% 02 HITHOUT SMOKE, 8,5~ 02 IN CORN SILK SMOKE, AND 10,4~ 02 IN TOBACCO SMOKE, DISCUSSION= "THE DIFFERENCE [IN MORTALITIES IN RATs EXPOSED TO CIGARETTE AND CORN SILK] WAS ATTRIBUTED TO HIGHER C0HB SATURATIONS AND TO NICOTINE IN THE TOBACCO SMOKE,# "THE FINDING THAT THE MORTALITY OF THE RATS GIVEN 0,045~ CO IN 8,3B 02 WAS MUCH LOWER THAN IN RATS EXPOSED TO TOBACCO SMOKE DESPITE SIMILAR COHB SATURATIONS EMPHASIZES THE IMPORTAtlCE OF ADDITIONAL FACTORS * n 10M/ NAT I ARTHR I~'T DIS, BETHESDA, MD/ ,RAT I ARTHR MET DIS, BETHESDA, MD ~IEMATOLOGICAL STUDY A~ INHALATION STUDY A~ PHYSIOLOGICAL STUDY A~ TOXICITY STUDY A,MALE DATA A~ RATS, THOUSAND, BLOOD CARBON MONOXIDE CIGARETTE SMOKE NOI~ASBOC A~ SURVIVAL RATE DECREASE CIGARETTE SMOKE ASSOC A, CIGARETTE SMOKE EXPOSURE A,CoRN SILK CIGARETTES A, OXYGEN EXPOSURE A~ CARBON MONOXIDE EXPOSURE A, CIGARETTE SMOKE TOXICITY A, CIGARETTE SMOKE PHYSIOLOGICAL EFFECTS A, HYPOXtA A~ SURVIVAL RATE CIGARETTE SMOKE NONASSOC A/ SPRAGUE DAWLEY RATS, CIGARETTE SMOKE EXPOSURE DURATION Aj SYNERGISM A~ RESPIRATORY RATE CHANGES CIGARETTE SMOKE ASSOC As RESPIRATORY RATE DECREASE A~ HYPOTHERMIA A, BLOOD LACTIC ACID CHANGES As BLOOD GLUCOSE INCREASE A~ BEHAVIOR CHANGES A~ HYPERVENTILATION A, BLOOD PYRUVIC ACID INCREASE A, NICOTINE PHYSIOLOGICAL. EFFECTS A, ANIMAL MODEL EXTRAPOLATION, GLYCOLYSIS INCREASE A, CIGARETTE SMOKE METABOLIC EFFECTS Aj CARBOXYHEMOGLOBIN A~ BODY TEMPERATURE DECREASE Aj ANAEROBIC GLYCOLYSIS A, ANAEROBIC METABOLISM A~ NICOTINE TOXICITY .Aj ADDITIVE EFFECTS A, BLOOD CARBON MONOXIDE INCREASE CIGARETTE CTR 98 CONG 01021

w d b tl HK0270016 27426 SMOKE ASSOC A., CIGARETTE SHOKE cOMPOSITION As CAR~ON MONOXIDE PHYSIOLOGICAL EFFECTS A/ SMOKING PL~CHINES As CIGARETTE TAR CONTE.NTs CIGARETTE NICOTINE CONTENTs CHLOROFORM "ANESTHESIA As AIR CAI~ON HONOXIDE CONTENTs ,o SPECTROPHOTOMETRYs BLOOD ANALYSIS As A!R OXYGEN CONTENTs STATISTICAL: ANALYSISs PtICOTINE ADRENERGIC EFFECTS A~ EPINEPHRINE RELEASE As HEART RATE INCREASE $HOKING CAUSATION ls HEART RATE INCREASE NICOTINE CAUSATION .1;HYPOXIA~ CIGARETTE SHOKINGs ELECTROCARDIOGRAM CHANGES SHOKING CAUSATION 1~ SPECIFIC AIRWAY CONDUCTANCEs ARTERIAL OXYGEN SATURATION DECREASE As HICOTINE RESPIRATORY EFFECTS As AIRt~rAY RESISTANCE INCREASE As ALTITUDE FACTORSs VISUAL ACUITY DECREASE CARgON HONOXIDE CAUSATION ].'j TOTAL BODY EXPOSURE CHAttER A/ ENGLISH LANGUAGE, BETHESDA HI) RESIDENCE~ USA RESIDENCE C:II~ 98 Z:OHG 01022