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t A Division of Lo.ws Theatres, Inc., Research Gnter, 420 English Street. P.O. Box 21668, Gransboro, North Carolina 27420 ~ January 14, 1985 Dr. Carol J. Henry Microbiological Associates 5221 River Rd. Bethesda, MD 20816 Dear Dr. Henry: We have reviewed the following three Draft Reports entitled "The Effect of Inhalation of Reference and Test Cigarette Smoke on Sister Chromatid Exchange in Mice." we have these coimaents and questions regarding the reports: Study No. 1-2398.013 with D1, D10, and D17 ./1. On page 2, under Data with Animal Models: a. line 3 - "SCE" should be plural. b. line 9 - the Benedict reference date should be 1984. This should also be changed in the References section J 2. on page 14. c. line 10 - "responsive" is misspelled. On page 3, line 2: "marrow" is misspelled. J 3. On page 4, line 10: the text should read "TPM was col- lected." J 4. On page 5, paragraph 2, line 4: "significantly" is mis- spelled. ,/ 5. On page 6, Cyclophosphamide was not included as a biological reagent. ./ 6. On page 7, first complete paragraph: a. line 4 - the text should read "which was 3 per cage." b. line 8 - should "ad libitum" be underlined? Go ,/7. On page 9, next to last line: "SCE" should be plural. aD tC CC J8• On page 10, paragraph 2, line 6: the "and" should be deleted. O ~

1 ~ 9. On page 11, line 4: the text states that certain clinical observations were made in all groups except Group 7. What . was observed in Group 7? 10. In comparing the references in section IX of all three studies to the references cited in the Benedict et al., 1984 paper, the following discrepancies were noted. Corrections in the draft reports will need to be made in the References sections, and in some cases, the reference in the text will also need correcting. a. Ardito references: "Lambert" is in the draft report, 4"Lamberti" in the paper. - b. 1 Basler reference: "SCE's" should be "SCEs". c. jHollander reference: Borgaonkar's initials are "D.S.' in the draft report, "D.A." in the paper. d. /Husgafvel-Pursiainen reference: name in paper is spelled "Pursiainnen". e. ,/Korte reference: in the paper, "Cytogenetic" is singular. f. /Lambert reference: "Lindblad" is in the draft report, "Lindbland" in the paper. g. ,. Obe reference: 'Hafning" is in the draft report, "Fahning" in the paper. 11. Should page 16 be numbered (at the bottom of Table 1)? ,/ 12. In Table 4, in the titles of columns 3 and 4: "SCE" should be plural. Study No. 1-2479.013 with D7, D13, and D23 ,/1. On page 2, under Data with Animal Models, line 2: "SCE" should be plural. .~ 2. On page 7, paragraph 2, lines 3-4: the text should read "which was 3 per cage." ,/3. On page 8: a. line 7- a parenthesis should follow "sessions". b. line 8-"SCE" should be plural. v/4. On page 11, paragraph 1: 'SCE" should be plural on lines 2,3, and 4. ~' 5. Should page 15 be numbered? m ,/6. In Table 1, the word "Regimen" under "Group Number/" should ~ be deleted. tj O .i7. In Table 4, in the titles of columns 3 and 4: "SCE" should CMaD be plural. - 2

Study No. 1-2480.013 with D14, D15, and D19 On page 2, under Data with Animal Models, line 2: "SCE" should be plural. /2. On page 6, paragraph 2, line 3: the text should read "except Group 10 which was housed." ,/3. On page 7, in the text in the middle of the page: ~ a. line 7: a parenthesis should follow "sessions". ,/b. line 8: "SCE" should be plural. ,/4. In Table 1, the word "Regimen" under "Group Number/" should be deleted. ~ 5. In Table 3, footnote "b" at the bottom": should this be . "mean" rather than "median" in this statement? V 9, S4t-v =~.a If you have any questions, please feel free to call. ~- i &4_ AAAP d• ~`S/ Ila..J* SincerelX. /u's a- Connie~J. Stone, Ph.D., D.A.B.T. CJS/lp:1 3