Philip Morris
Diesel Exhaust Is A Pulmonary Carcinogen in Rats Exposed Chronically by Inhalation
Fields
- Author
- Griffith, W.C.
- Henderson, R.F.
- Jones, R.K.
- Mauderly, J.L.
- Mcclellan, R.O.
- Henderson, R.F.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2063594010/4240
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- Site
- R530
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- CARCHMAN,RICHARD/OFFICE
- Litigation
- Iwoh/Produced
- Type
- SCRT, REPORT, SCIENTIFIC
- Named Organization
- Fundamental + Applied Toxicology
- Date Loaded
- 07 Jun 1999
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#78
AUTHOR: MAUDERLY, JOE L., ROBERT K. JONES, WILLIAM C. GRIFRTH, ROGENE F.
HENDERSON, AND ROGER O. McCLELLAN
DATE: 1987
TITLE: DIESEL EXHAUST IS A PULMONARY CARCINOGEN IN RATS EXPOSED
CHRONICALLY BY INHALATION
CITATION: FUNDAMENTAL AND APPLIED TOXICOLOGY 9:208-221 (1987)
STUDY DESIGN: Male and female F34 rats were exposed 7 hr/day, 5 days/week for up to 30
months to automotive diesel engine exhaust at soot concentrations of 0.35, 3.5 or 7.0 mg/ms or
were sham-exposed to clean air. Rats were terminated at 6-month intervals to measure lung
burdens of diesel soot and for histopathology.
RNDINGSIRESULTS:
Survival and body weight were unaffected by exposure. Focal fibrotic and proliferative lung
disease accompanied a progressive accumulation of soot in the lung. The prevalence of lung
~mors was significantly increased at the high (13%) and medium (4%) dose levels above the
control prevalence (1%). Four tumor types, all of epithelial origin were observed: adenoma,
adenocarcinoma, squarnous cyst, and squamous cell carcinoma. Logistic regression modeling
demonstrated a significant relationship between tumor prevalence and both exposure
concentration and soot tung burden.
CONCLUSIONS:
These results demonstrate that diesel exhaust, inhaled chronically at a high concentration, is a
pulmonary carcinogen in the rat.
