Philip Morris
Etude Des Effects De La Fumee De Cigarettes Par Inhalation Chezle Rat
Fields
- Author
- Chouroulinkov, I.
- Michiels, F.M.
- Montagne, J.J.
- Michiels, F.M.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2063594010/4240
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- Site
- R530
- Area
- CARCHMAN,RICHARD/OFFICE
- Litigation
- Iwoh/Produced
- Type
- SCRT, REPORT, SCIENTIFIC
- Named Organization
- Biologie
- Environment Maiaout
- Hamburg
- Medicine
- Environment Maiaout
- Date Loaded
- 07 Jun 1999
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AUTHOR: MICHIELS, F.M., J.J. MONTAGNE AND I. CHOUROULINKOV
DATE: 1982
TITLE: ETUDE DES EFFETS DE LA FUMEE DE CIGARETTES PAR INHALATION CHEZ LE
RAT
CITATION: MEDECINE/BIOLOGIE/ENVIRONMENT MAI-AOUT 56-62 (1982)
STUDY DESIGN: Male and female Wistar rats were exposed to cigarette smoke on a Hamburg
type II smoke machine 5 time/day, 5 day/week, for a period of 12 months. Blood samples were
drawn every 6 weeks and histological analysis was performed at the end of the experiment.
RNDINGS/RESULTS:
Cigarette smoke induced a reduction of blood glucose, cholesterol, triglycerides, acid
phosphatase and cholinesterase, while an increase of alkaline phosphatase, alpha-l-antitrypsin
and aspartate aminotransferase was observed.
Smoke-induced pathological changes of the respiratory tract were classified into inflammatory
lesions and proliferative lesions. The incidence of inflammatory lesions was negligible in the
larynx and the trachea, depended on the type of cigarette in the bronchus, and was most
pronounced in the lung. Proliferative lesions were observed in the larynx, trachea and lung, but
infrequently observed in the bronchus.
Ultrastructural studies showed, beyond alteration in several organelles, the presence of tar, not
only in the macrophages, but also in the epithelial cells.
CONCLUSIONS:
This experimental model, permits the evaluation of the biological effects of cigarette smoke and
is applied with success to the study of experimental cigarettes.
NOTE', ARTICLE IN FRENCH WITH ENGLISH SUMMARY
