Philip Morris
Bronchial Reactivity to Inhaled Methacholine in Cigarette Smoking Baboons
Fields
- Author
- Johanson, W.G., J.R.
- Roehers, J.D.
- Rogers, W.
- Roehers, J.D.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2063594010/4240
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- Site
- R530
- Area
- CARCHMAN,RICHARD/OFFICE
- Litigation
- Iwoh/Produced
- Type
- SCRT, REPORT, SCIENTIFIC
- Named Organization
- J Appl Physiol
- Respirat Environ Excercise Physiol
- Date Loaded
- 07 Jun 1999
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AUTHOR: ROEHERS, JOHN D., WALTER ROGERS, AND W.G. JOHANSON, Jr.
DATE: 1981
TITLE: BRONCHIAL REACTIVITY TO INHALED METHACHOLINE IN CIGARETTE-
SMOKING BABOONS
CITATION: J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50(4):-754-760, 1981
STUDY DESIGN: 31 young-adult male feral baboons (age approx 6-8 years) were randomly .
assigned to cigarette-smoking or sham-smoking groups. The animals were taught to puff on lit
cigarettes (smokers) or on a similar resistance (shams). Details of training methods, cigarette
composition and experimental design were presented in this paper. After 6 pack-years of
smoking (40 cigarettes/day for 3 years), airway reactivity was studied. The animals were
anesthetized and intubated for measurement of lung volumes, compliance, and expiratory flow
with air and 80% helium-20% oxygen using both partial expiratory flow-volume and maximal
expiratory flow-volume maneuvers.
RNDING/RESULTS:
Baseline lung function was similar in smokers and shams. Following methacholine, residual
volume increased significantly in shams but not in smokers. Smokers showed significantly
greater postchallange flow rates than did shams, and the dose of methacholine required to
produce a 20% decrement in flow was significantly greater in smokers.
CONCLUSIONS:
Chronic cigarette smoking in a nonhuman primate model decreases air reactivity to inhaled
methacholine even when base-line lung function is normal.
