Product Design
Proposal to Continue Project B412 - Nicotine Manipulation, Migration & Reaction Mechanisms
Abstract
Proposes continuation of Project B412. Notes recent findings indicate additives increase nicotine migration and previous work shows malic acid added to cigarette paper increases nicotine in peripheral smoke. States project will optimize additives for increased nicotine delivery and controlling smoke pH will result in "satisfactory taste and impact". Suggests additional nicotine chemistry mechanisms studied may yield results for publication. Notes the project objectives: "to optimize migration of nicotine to the periphery of the cigarette,...improve the delivery to mainstream smoke,...understand the mechanisms of nicotine reactions with selected salts and acids." Submits a time-line and man-hours required for technical analysis.
Fields
- Author
- Ireland, M.S.
- Recipient
- Minnemeyer, Harry J. (Lorillard R&D Dept.; worked on nicotine augmentation project)
- Hypothesis
- Design changes over timeChanges in cigarette design over the past half century.
- Nicotine transport, transfer, and uptake
Design changes which alter nicotine delivery or effect how the product causes and maintains dependence, including transfer of nicotine from tobacco to smoke, and uptake into the body.- Use of additives
Modification of tobacco products through use of additives and measuring effects on dependence, behavior, and toxicity.- Use of filters, paper, and ventilation
Modification of tobacco products through use of filters, paper, and ventilation, and measuring effects on dependence, behavior, and toxicity. - Nicotine transport, transfer, and uptake
- Keyword
- Flavor/ Taste (Attribute measure)
- Impact (Throat grab)
- Nicotine delivery (Smoke nicotine or nicotine yield)
- Nicotine manipulation
- Smoke pH
Acidity/ baseness, scale from 0-14, 7 neutral - Impact (Throat grab)
- Additive
- Malic acid
- Smoke Constituent
- Nicotine
- Design Component
- Nicotine transfer efficiency (NTE)
- Nicotine content (Tobacco nicotine content)
Total nicotine in the unburnt tobacco rod - Nicotine content (Tobacco nicotine content)
- Operation/Project
- Project B412
- Named Organization
- LRC
- R&D
- B.A.T. UK & Export Ltd. (British American Tobacco UK)
British American Tobacco United Kingdom Ltd.- Brown & Williamson Tobacco Corporation (B&W)
Subsidiary of BAT U.S., located in Louisville, KY. - R&D
- Subject
- nicotine technology
- pH Manipulation (Technology)
- Smoke Constituents
- Smoke Nicotine (Measures)
- Smoke pH (Measures)
- pH Manipulation (Technology)
Document Images
,4
'220n~llar/,
MEMORANDUM
January 28, 1981
TO: Dr. H. J. Minnemeyer
FROM: M. S. Ireland
SUBJECT: Proposal to continue project B412 - Nicotine
Manipulation, Migration & Reaction Mechanisms
Recent findings have indicatedthat certain additives,when
added to the tobacco, can accelerate the rate of migration of
nicotine. Previous work has shown that cigarettes made with
malic acid added to the cigarette paper, increases the amount of
nicotine in the periphery of the tobacco and on the paper. This
has shown a slight increase in the nicotine delivery to the main-
stream smoke.
Continued work on this project will seek to optimize both
tobacco additive and paper additive for maximum migration and
increasedidelivery of nicotine to the mainstream smoke with
rapidequilibration of the product. In addition, it would be
desirable to control smoke pH so that a satisfactory taste and
impact can be obtained.
Additional nicotine reaction mechanisms will be studied using
available technology and, since little has been published in this
area, it is felt that this approach might yield information worthy
of publication.
The technical approach which will be followed is attached.
/tb
O
Attachment O
O
CJ1.
m
FA
Cn
Project #'
RESEARCH AND DEVELOPMENT
PROJECT REQUEST
Project Name: Nicotine Manipulation, Migration Date:
& Reaction Mechanisms - Continuation of Research Project ~
Principal Project Objectives -
The principle objectives of this project are to optimize
migration of nicotine to the periphery of the cigarette and
improve the delivery to mainstream smoke, and to understand
the mechanisms of nicotine reactions with selected salts &
acids.
TECHNICAL ANALYSIS
Pattern for
Technical
Approach
Equipment**
and
LRC** Extra-
Time _ Manhours Outside ordinary
Required Required Services Materials
1. Determination of tobacco additives
that accelerate migration 2/2/81-6/1/81 300
2. Determinatiomof paper additives
that facilitate migration 2/2/81-6/1/81 170
3. Reactiommechanisms 2/2/81-8/3/81, 60
4. Optimization 6/1/81-7/6/81i 80
5. Select additives that optimize pH 6/1/81-7/6/81 80
6. Investigate physical-chemical
changes 5/4/81-9/7/81 70 ~
Q
CA
7. Orgpnoleptic evaluations 8/3/81!-9/7/81 40 N
GD
8. Report 9/7/81-9/21/81 80
_ ~
880Tota1
Hours ~
*Project Leader R. W. Slaven
*Project Group Member(s R. W. Hurst
J. M. Johnson
Total R & D Cost
**Estimated.
