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Product Design

Winston - Marlboro Comparison Study

Date: 1990
Length: 22 pages
508031311 -1332
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Abstract

Study tests smokers' plasma nicotine concentrations after smoking Winston or Marlboro cigarettes. Uses human subjects to smoke one brand per appearance, with one puff every forty five seconds for a total of nine puffs. Presents results from Project GT tests. States the goal of developing a product with reduced tar comprable to an FFLT cigarette through the addition of nicotine levulinate, similar to Project GTX.

Fields

Hypothesis
Behavior Targeting
Cigarette's effect of enhancing/mitigating specific behaviors
Keyword
Behavior targeting
Blood nicotine
Brand differences
Consumer acceptability (Consumer preference)
Flavor/ Taste (Attribute measure)
Human testing
Nicotine delivery (Smoke nicotine or nicotine yield)
Smoothness/Harshness (Attribute measure)
Additive
Levulinic acid
Smoke Constituent
Nicotine
Total particulate matter
Carbon dioxide
Design Component
G7 (RJR @reconstituted_tobacco)
Operation/Project
Project GT
Project GT-X
Project XGT (1989 Smoker Behavior Study)
Study to compare puffing and breathing patterns and plasma nicotine concentrations.
Named Organization
Federal Trade Commission (Enforcement agency for laws against deceptive advertising)
Enforces laws against false and deceptive advertising, including ads for tobacco products. Ensures proper display of health warnings in ads and on tobacco products;collects and reports to Congress information concerning cigarette and smokeless tobacco advertising, sales expenditures, and the tar, nicotine, and carbon monoxide content of cigarettes.
Brand
Winston (RJR)
Marlboro (PM)
Premier Brand Cigarettes ("Smokeless" cigarette by RJR in the early 1990s)
"Smokeless" cigartte marketed by RJR in the early 1990s. Stationary furnace devices such as this operate by separating the combustion material (carbon) from the aerosol generating material (mostly glycerol) such that the inhaled by-products yielded upon smoking are the distilation products (glercerol and water) rather than combustion products (nicotine + smoke constituents). This is one reason why this product failed in market. Flavoring is derived from tobacco, nicotine, the paper roll and sprayed dried extract. Addition flavor of primarily rasberry ketone and chocolate was also added to enhance tobacco taste and give rise to a "pleasing aroma" in the smoke. This added flavor was a major reason that Premier failed in market as the taste was very different from conventional cigs.
Vantage (RJR)
Now (RJR)
Subject
Levulinic Acid (Additives)
reduces the harshness of cigarettes
Blends (Design)
nicotine technology

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Page 1: ehv04d00 Log in for more options!
iVINSTON - MARLBORO COMPARISON STUDY SUBJEC TS : 12 Male Smokers. Regular Brand Wins ton (6) or Marl,boro (6). SMOKING: Randomly assigrred to smoke Winston or Marlboro >s t day. Smoked the o ther cigare tte on the 2nd day. AlONI TOR: Puff-Profile Pa tterns Brea thing Pa tterns Plasma lUico tine Concentra tions EXPERIMENTAL PARADI GM Smoke l Cigare tte Ea ch Appearance l Puff Every 45 Seconds, To tal = 9 Puffs Blood Samples Dra wn a t-2. 5; 0, 1, 3, 5, 7.5 10, 15, And 20 MIN (Rela tive To Ligh ting Cigare tte)
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QUESTION: DO SMOKERS'PLASMA NICOT/NE CONCENTRATIONS DIFFER FOLLOWING THE SMOKING OF W/NSTON OR MARLBORO C/GARETTES? 4
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1987 PRQJECT GT TEST` NOW :. WINSTON 1986 TEST 1986 TEST a p f . * . . . NOW ...._. A - 6 8 10 Time. Post Lighting Cigarette (Min) NOW GT 14 16 1', 4 1i :'x f r ~ EtiEt E080S
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BRAND CHOICE CONSUMER ACCEPTANCE SMOKER BATISFACTMON PHYSIOLOGICAL, PHARMACOLOGICAL ~ PSYCHOPHYSiCAL RESPONSES SMOKE COMPONENTS ABSORBED I BREATHING BEHAV10ft f SENSdRY ASPECTS'TASTE', SMELL.,'FEEL' SMOKE QUALITY I SMOKE YIELDS - SMOKE CHEMISTRY PUFFlNG BEHA\AOfi
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WINS TON - MARLBORO S TUD Y Maximum Ni co ti ne 'Ri se ' Wl NSTON MARLBORO All Smokers 14.2 16.4 (9.1-24.0) (6.9-31.5) ~ ~ Wfnston Smokers 14.9 18.3 (9.1-24.0) (9.9-31.5) ' Marlboro Smokers 13.6 14.7 (10.4 - 19.6) (6.9 - 23.9)
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• C. Thompson, RDR 1954, No. 11 - Studied the effects of the addition of organic acids to burley tobacco blends. Thirty acids tested. Many resulted in significantly improved "smoothness" of the smoke. • 1986 - PREMIER team explores ways to improve "harshness". Numerous organic acids evaluated, for "smoothing" effect. Levulinic acid found to improve "smoothness" without significant off-taste. • 1987 - J. Lawson transfers to Brand R&D, VANTAGE team. Encounters harshness issues with VANTAGE. Begins evaluation of levulinic acid in tobacco burning cigarettes. Finds: 1. Reduction in harshness. 2. Reduction in strength (Impact. 3. Reduction in tobacco taste. 4. Reduction in 70+ scores. Project GT begins in Brand R&D.
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~ Project GT - Objective: Develop a product with reduced 'tar' (ULT product) comparable to an FFLT cigarette. ~ In an attempt to improve "impact" and tobacco taste, Project GT explored the addition of Nicotine Levulinate (salt form) to 2 ULT cigarettes, NOW and WI NSTON ULTRA LIGHT 100s. Results: 1. T/N ratios N 4 - 5. 2. Extremely smooth. 3. Little or no impact. ~ Biobehavioral studies: 1. No differences in smoking behavior between cigarettes with and without nicotine levulinate. 2. Significantly increased mainstream smoke yields of nicotine reflected in plasma concentrations. NeY3
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I EXPERIMENTAL PROTOCOL N ICOTI N E LEVU LI NATE STU DY - 1987 SUBJECTS ABSTAIN FROM SMOKING 1 HOUR BEFORE EACH TEST I ONE APPEARANCE PER WEEK FOR 2 WEEKS I SUBJECTS: 15 MAILES, 6 FEMALES I SUBJECTS SMOKE NOW - (TEST) OR WUL -(iEST) MONITOR PUFFING BEHAVIOR & BREATHING BEHAVIOR BLOOD SAMPLES COLLECTED AT: BASELINE -2 AND 0 MIN 1, 3, 5, 7.5,10,15 & 20 M IN GC - NPD DETERMINATION OF NICOTINEI COTININE . .
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PLASMA NICOTINE "RISE; FEMALES (n=6)
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1990 - PROJECT GTX STUDIES • ULT cigarettes with enhanced nicotine yields and good smoking characteristics can be produced. By incorporating Nicotine Levulinate (salt) into the tobacco blend, significant reductions in harshness normally associated with low T/N products can be achieved. UNANSWERED QUESTIONS • How and why does the nicotine levulinate "masking" phenomenon work? V What cigarette design parameters are important to this phenomenon? 'Tar' Yields Nicotine Yields Tobacco Nicotine Air Dilution Ranges Interactions with Top Dressings REST Tobaccos • How much harshness can be masked? How much mainstream smoke nicotine is enough? How much is too much? How does the form of nicotine in the smoke interact with the sensory and physiological effects?

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