Product Design
Subject: Thermal Stability of Nicotine, Levulinic Acid, Nicotine Levulinate and Sodium and Calcium Levulinate
Abstract
Reports on analyses for volatility and thermal stability of nicotine salts and inorganic salts of levulinic acid. Presents information available in the literature, and a detailed description of thermal stability of the compounds. States that inorganic salts of levulinic acid (Na or Ca) have very low volatility. Notes the very high thermal stability of nicotine levulinate.
Fields
- Author
- Perfetti, Thomas Albert, Ph.D. (RJR Flavorist)
- Hypothesis
- Use of additivesModification of tobacco products through use of additives and measuring effects on dependence, behavior, and toxicity.
- Keyword
- Acidity (Low pH)
- Nicotine delivery (Smoke nicotine or nicotine yield)
- Additive
- Levulinic acid
- Smoke Constituent
- Nicotine salts
- Named Organization
- HRRC
- Subject
- acids (additives)
- Levulinic Acid (Additives)
reduces the harshness of cigarettes- nicotine technology
- Levulinic Acid (Additives)
Document Images
WR Interoffice Memorandum
TO: Dr. J. H. Reynolds
FROM: T. A. Perfetti
DATE: July 13, 1990
SUBJECT: Thermal Stability of Nicotine, Levulinic Acid, Nicotine Levulinate and
Sodium and Calcium Levulinate _
In the HRRC's response to Inquiry R9006, Section 3, a request for volatility and
thermal stability data on nicotine salts and inorganic salts of levulinic acid was requested.
Please find enclosed the TG/GC/MS analyses of the above mentioned compounds. The
TG/GC/MS scans give a detailed description of the thermal stability of the compounds
above. Volatility information on the inorganic salts was not found in the literature but as
is seen in Reference 3 (All papers on literature found to deal with inorganic salts of
levulinic acid are attached.) the calcium salt was stable for 24 hrs. at 130°C. Based on
this information and the TG/GC/MS data, it should be surmised that inorganic salts of
levulinic acid (Na or Ca) have very low o at'li . MSDS sheets are also enclosed. I
hope this closes the door on the question of stability and volatility for the inorganic salts
of levulinic acid.
Please note the very high thermal stability of nicotine levulinate (decomposition
range between 182-350°C). The decomposition temperature range for levulinic acid was
201-532°C and that of nicotine was 132-246°C.
If you have further questions, please let me know.
Sincerely,
/trr
Enclosures
xc: Dr. B. M. Lawrence
Dr. R. L. Suber
Dr. M. E. Stowe
Mr. L. A. Lyerly
